Study of glucose uptake activity of Helicteres isora Linn. fruits in L-6 cell lines

The effect of hot water extract of fruits of Helicteres isora on glucose uptake was studied in rodent skeletal muscle cells (L-6 cells) involved in glucose utilization. H. isora is an antidiabetic medicinal plant being used in Indian traditional medicine. Hot water extracts were analysed for glucose...

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Bibliographic Details
Published in:International journal of diabetes in developing countries 2009-10, Vol.29 (4), p.170-173
Main Authors: Gupta, R N, Pareek, Anil, Suthar, Manish, Rathore, Garvendra S, Basniwal, Pawan K, Jain, Deepti
Format: Article
Language:English
Subjects:
Folk medicine
Glucose
Herbal medicine
Muscular system
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Summary:The effect of hot water extract of fruits of Helicteres isora on glucose uptake was studied in rodent skeletal muscle cells (L-6 cells) involved in glucose utilization. H. isora is an antidiabetic medicinal plant being used in Indian traditional medicine. Hot water extracts were analysed for glucose uptake activity and found to be significantly active at 200 mug/ml dose comparable with insulin and metformin. Elevation of glucose uptake by H. isora in association with glucose transport supported the upregulation of glucose uptake. It was concluded that hot water extract of H. isora activate glucose uptake in L-6 cell line of mouse skeletal muscles.
ISSN:0973-3930
1998-3832
DOI:10.4103/0973-3930.57349