Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentratio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Biomedical Optics 2010-01, Vol.15 (1), p.010510-010510
Main Authors: Kim, Chulhong, Qin, Ruogu, Xu, Jeff S, Wang, Lihong V, Xu, Ronald X
Format: Article
Language:English
Subjects:
Animals
Chickens
Contrast Media - chemistry
Encapsulation
Imaging
JBO Letters
Lactic Acid - chemistry
Microbubbles
Microorganisms
Nanocomposites
Nanomaterials
Nanoparticles - chemistry
Nanostructure
Nanotechnology - methods
Phantoms, Imaging
Polyglycolic Acid - chemistry
Ultrasonography - methods
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3302808