Cytokines and Their STATs in Cutaneous and Visceral Leishmaniasis

Cytokines play a critical role in shaping the host immune response to Leishmania infection and directing the development of protective and non-protective immunities during infection. Cytokines exert their biological activities through the activation and translocation of transcription factors into th...

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Bibliographic Details
Published in:BioMed research international 2010-01, Vol.2010 (2010), p.1-6
Main Authors: Cummings, Hannah E., Satoskar, Abhay R., Tuladhar, Rashmi
Format: Article
Language:English
Subjects:
Activation
Animals
Biomedical research
Biotechnology
Chemotherapy
Colleges & universities
Cytokines
Cytokines - immunology
Genes
Humans
Immune system
Immunity
Immunity, Innate - immunology
Leishmania
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Visceral - immunology
Models, Immunological
Nitric oxide
Parasites
Parasitic diseases
Proteins
Receptors
Review
Signatures
STAT Transcription Factors - immunology
Transducers
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Summary:Cytokines play a critical role in shaping the host immune response to Leishmania infection and directing the development of protective and non-protective immunities during infection. Cytokines exert their biological activities through the activation and translocation of transcription factors into the nucleus whether they drive the expression of specific cytokine-responsive genes. Signal transducer and activator of transcription (STATs) are transcription factors which play a critical role in mediating signaling downstream of cytokine receptors and are important for shaping the host immune response during Leishmania infection. Here we discuss the signature cytokines and their associated STATs involved in the host immune response during cutaneous and visceral leishmaniasis.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/294389