A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21)

t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphas...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of human genetics 2008-01, Vol.14 (1), p.20-22
Main Authors: Trivedi, PJ, Patel, PS, Brahmbhatt, MM, Patel, BP, Gajjar, SB, Iyer, RR, Parikh, EH, Shukla, SN, Shah, PM, Bakshi, SR
Format: Article
Language:English
Subjects:
Acute myeloid leukemia, cytogenetics, fluorescence in situ hybridization
Case Report
Case studies
Chromosomes
Complications and side effects
Genetics
Health aspects
Leukemia
Radiotherapy
Trisomy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype.
ISSN:0971-6866
1998-362X
DOI:10.4103/0971-6866.42323