Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer: The California Teachers Study

Results from epidemiologic studies of hormone therapy use and colon cancer risk are inconsistent. This question was investigated in the California Teachers Study (1995-2006) among 56,864 perimenopausal or postmenopausal participants under 80 years of age with no prior colorectal cancer by using Cox...

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Bibliographic Details
Published in:American journal of epidemiology 2010-02, Vol.171 (4), p.415-425
Main Authors: DELELLIS HENDERSON, Katherine, LEI DUAN, SULLIVAN-HALLEY, Jane, HUIYAN MA, CLARKE, Christina A, NEUHAUSEN, Susan L, TEMPLEMAN, Claire, BERNSTEIN, Leslie
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Biological and medical sciences
California - epidemiology
Colonic Neoplasms - epidemiology
Colonic Neoplasms - pathology
Colonic Neoplasms - prevention & control
Colorectal cancer
Faculty - statistics & numerical data
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hormone Replacement Therapy
Humans
Medical sciences
Menopause
Middle Aged
Neoplasm Invasiveness
Original Contributions
Pneumology
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surveys and Questionnaires
Tobacco, tobacco smoking
Toxicology
Tumors
Tumors of the respiratory system and mediastinum
Womens health
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Summary:Results from epidemiologic studies of hormone therapy use and colon cancer risk are inconsistent. This question was investigated in the California Teachers Study (1995-2006) among 56,864 perimenopausal or postmenopausal participants under 80 years of age with no prior colorectal cancer by using Cox proportional hazards regression. Incident invasive colon cancer was diagnosed among 442 participants. Baseline-recent hormone therapy users were at 36% lower risk for colon cancer versus baseline-never users (baseline-recent users: relative risk (RR) = 0.64, 95% confidence interval (CI): 0.51, 0.80). Results did not differ by formulation. Estimated risk was lower among baseline-recent hormone therapy users with increasing duration between 5 and 15 years of use (RR = 0.49, 95% CI: 0.35, 0.68), but the trend did not persist in the longest duration group, more than 15 years of use (RR = 0.69, 95% CI: 0.52, 0.92; P(trend) = 0.60). Long-term recreational physical activity, obesity, regular use of nonsteroidal antiinflammatory medications, and daily alcohol intake did not modify these effects; baseline-recent use was more strongly associated with colon cancer risk among women with a family history of colorectal cancer (P(heterogeneity) = 0.04). Baseline-recent hormone therapy use was inversely associated with invasive colon cancer risk among perimenopausal and postmenopausal women in the California Teachers Study.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwp434