Bioresponsive nanosensors in medical imaging

Superparamagnetic iron oxide nanoparticles have been established as sensitive probes for magnetic resonance imaging (MRI). While the majority of specific nanosensors are based on sterically stabilized iron oxide particles, the focus of this review is on the use of very small iron oxide particles (VS...

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Bibliographic Details
Published in:Journal of the Royal Society interface 2010-02, Vol.7 (Suppl-1), p.S83-S91
Main Author: Schellenberger, Eyk
Format: Article
Language:English
Subjects:
Annexins - chemistry
Apoptosis - physiology
Apoptosis Imaging
Citric Acid - chemistry
Diagnostic Imaging - instrumentation
Diagnostic Imaging - methods
Enzyme Activity
Ferric Compounds - chemistry
Fluorescent Dyes
Iron Oxide Particles
Magnetic Resonance Imaging - methods
Magnetics
Matrix Metalloproteinase
Models, Molecular
Nanostructures
Static Electricity
Superparamagnetic
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Summary:Superparamagnetic iron oxide nanoparticles have been established as sensitive probes for magnetic resonance imaging (MRI). While the majority of specific nanosensors are based on sterically stabilized iron oxide particles, the focus of this review is on the use of very small iron oxide particles (VSOPs) that are electrostatically stabilized by an anionic citrate acid shell. We used VSOPs to develop target-specific as well as protease-activatable nanosensors for molecular MRI.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2009.0336.focus