Physical activity, sedentary behavior, and endometrial cancer risk in the NIH‐AARP Diet and Health Study

Consistent with a strong hormonal etiology, endometrial cancer is thought to be influenced by both obesity and physical activity. Although obesity has been consistently related to risk, associations with physical activity have been inconclusive. We examined relationships of activity patterns with en...

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Bibliographic Details
Published in:International journal of cancer 2009-05, Vol.124 (9), p.2139-2147
Main Authors: Gierach, Gretchen L., Chang, Shih‐Chen, Brinton, Louise A., Lacey, James V., Hollenbeck, Albert R., Schatzkin, Arthur, Leitzmann, Michael F.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Body Mass Index
Cohort Studies
Diet
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - etiology
Exercise
exercise/physiology
Female
Female genital diseases
Follow-Up Studies
Gynecology. Andrology. Obstetrics
health behavior
Humans
Incidence
Medical sciences
Middle Aged
Motor Activity
National Institutes of Health (U.S.)
Obesity - complications
Postmenopause
prospective studies
recreation/physiology
Risk Assessment
Surveys and Questionnaires
Tumors
United States - epidemiology
Women's Health
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Summary:Consistent with a strong hormonal etiology, endometrial cancer is thought to be influenced by both obesity and physical activity. Although obesity has been consistently related to risk, associations with physical activity have been inconclusive. We examined relationships of activity patterns with endometrial cancer incidence in the NIH‐AARP Diet and Health Study cohort, which included 109,621 women, ages 50–71, without cancer history, who in 1995–1996 completed a mailed baseline questionnaire capturing daily routine and vigorous (defined as any period of ≥20 min of activity at work or home causing increases in breathing, heart rate, or sweating) physical activity. A second questionnaire, completed by 70,351 women, in 1996–1997 collected additional physical activity information. State cancer registry linkage identified 1,052 primary incident endometrial cancers from baseline through December 31, 2003. In multivariate proportional hazards models, vigorous activity was inversely associated with endometrial cancer in a dose‐response manner (p for trend = 0.02) (relative risk (RR) for ≥5 times/week vs. never/rarely = 0.77, 95% confidence interval (CI): 0.63–0.95); this association was more pronounced among overweight and obese women (body mass index ≥25; RR = 0.61, 95% CI: 0.47–0.79) than among lean women (body mass index
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.24059