The development of performance-monitoring function in the posterior medial frontal cortex

Despite its critical role in performance-monitoring, the development of posterior medial prefrontal cortex (pMFC) in goal-directed behaviors remains poorly understood. Performance monitoring depends on distinct, but related functions that may differentially activate the pMFC, such as monitoring resp...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-02, Vol.49 (4), p.3463-3473
Main Authors: Fitzgerald, Kate Dimond, Perkins, Suzanne C., Angstadt, Mike, Johnson, Timothy, Stern, Emily R., Welsh, Robert C., Taylor, Stephan F.
Format: Article
Language:English
Subjects:
Adult
Aging
Algorithms
Behavior
Brain
Brain Mapping - methods
Cognition - physiology
Female
Frontal Lobe - physiology
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Task Performance and Analysis
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Summary:Despite its critical role in performance-monitoring, the development of posterior medial prefrontal cortex (pMFC) in goal-directed behaviors remains poorly understood. Performance monitoring depends on distinct, but related functions that may differentially activate the pMFC, such as monitoring response conflict and detecting errors. Developmental differences in conflict- and error-related activations, coupled with age-related changes in behavioral performance, may confound attempts to map the maturation of pMFC functions. To characterize the development of pMFC-based performance monitoring functions, we segregated interference and error-processing, while statistically controlling for performance. Twenty-one adults and 23 youth performed an event-related version of the Multi-Source Interference Task during functional magnetic resonance imaging (fMRI). Linear modeling of interference and error contrast estimates derived from the pMFC were regressed on age, while covarying for performance. Interference- and error-processing were associated with robust activation of the pMFC in both youth and adults. Among youth, interference- and error-related activation of the pMFC increased with age, independent of performance. Greater accuracy associated with greater pMFC activity during error commission in both groups. Discussion: Increasing pMFC response to interference and errors occurs with age, likely contributing to the improvement of performance monitoring capacity during development.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2009.11.004