Effects of simulated weightlessness on liver Hsp70 and Hsp70mRNA expression in rats

Space flight is known to induce a number of hepatic physiological alterations. In this study, we investigated Hsp70 expressing features of rat liver under simulated weightlessness. Tail-suspension was used to simulate the weightlessness animal model. Forty-eight male Wistar rats were randomly assign...

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Published in:International journal of clinical and experimental medicine 2010-01, Vol.3 (1), p.48-54
Main Authors: Cui, Yan, Zhou, Jinlian, Li, Chenglin, Wang, Ping, Zhang, Ming, Liu, Zipei, Yi, Yong, Zhang, Jianzhong
Format: Article
Language:English
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Summary:Space flight is known to induce a number of hepatic physiological alterations. In this study, we investigated Hsp70 expressing features of rat liver under simulated weightlessness. Tail-suspension was used to simulate the weightlessness animal model. Forty-eight male Wistar rats were randomly assigned to 6 experimental groups and Hsp70 protein and mRNA expressions in the liver were detected by Western blot and RT-PCR respectively. The tail-suspension significantly increased Hsp70mRNA expression levels in rat liver (P
ISSN:1940-5901