IGF-1, oxidative stress and atheroprotection

Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion form...

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Published in:Trends in endocrinology and metabolism 2010-04, Vol.21 (4), p.245-254
Main Authors: Higashi, Yusuke, Sukhanov, Sergiy, Anwar, Asif, Shai, Shaw-Yung, Delafontaine, Patrice
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - therapeutic use
Apoptosis
Atherosclerosis - drug therapy
Atherosclerosis - pathology
Atherosclerosis - prevention & control
Biological and medical sciences
Endocrinology & Metabolism
Endothelium, Vascular - cytology
Fundamental and applied biological sciences. Psychology
Insulin-Like Growth Factor I - metabolism
Insulin-Like Growth Factor I - therapeutic use
Models, Animal
Muscle, Smooth, Vascular - pathology
Oxidative Stress
Stem Cells - physiology
Vertebrates: endocrinology
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Summary:Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion formation but also in lesion progression and destabilization. Although most growth factors are thought to promote vascular smooth muscle cell proliferation and migration, thereby increasing neointima, recent animal studies indicate that insulin-like growth factor (IGF)-1 exerts both pleiotropic anti-oxidant effects and anti-inflammatory effects, which together reduce atherosclerotic burden. This review discusses the effects of IGF-1 in models of vascular injury and atherosclerosis, emphasizing the relationship between oxidative stress and potential atheroprotective actions of IGF-1.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2009.12.005