Acute Immune Response to Mycobacterium massiliense in C57BL/6 and BALB/c Mice

Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 10⁶ CFU of an M. massiliense strain isolated from a nosocomial inf...

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Bibliographic Details
Published in:Infection and Immunity 2010-04, Vol.78 (4), p.1571-1581
Main Authors: Martins de Sousa, Eduardo, Bonfim de Bortoli, Fernando, Amaral, Eduardo Pinheiro, Batista, Aline Carvalho, Liberman Kipnis, Thereza, Marques Cardoso, Alessandra, Kipnis, André, Junqueira-Kipnis, Ana Paula
Format: Article
Language:English
Subjects:
Animals
Bacteremia - immunology
Bacteremia - pathology
Bacteriology
Biological and medical sciences
Brazil
Cross Infection - microbiology
Dendritic Cells - immunology
Disease Models, Animal
Female
Fundamental and applied biological sciences. Psychology
Granuloma - immunology
Granuloma - microbiology
Granuloma - pathology
Host Response and Inflammation
Humans
Interferon-gamma - immunology
Interleukin-17 - immunology
Killer Cells, Natural - immunology
Liver - microbiology
Liver - pathology
Lung - microbiology
Lung - pathology
Macrophages - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Microbiology
Miscellaneous
Mycobacterium - immunology
Mycobacterium - isolation & purification
Mycobacterium - pathogenicity
Mycobacterium Infections - immunology
Mycobacterium Infections - microbiology
Mycobacterium Infections - pathology
Spleen - microbiology
Spleen - pathology
Virulence
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Summary:Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 10⁶ CFU of an M. massiliense strain isolated from a nosocomial infection in Brazil. The results presented here show that M. massiliense is virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by IL-12 in BALB/c mice.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.00731-09