Methods in Mammalian Autophagy Research

Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate the process of autophagy. However, as autophagy involves dynamic and complicated processes, it is often analyzed incorrectl...

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Bibliographic Details
Published in:Cell 2010-02, Vol.140 (3), p.313-326
Main Authors: Mizushima, Noboru, Yoshimori, Tamotsu, Levine, Beth
Format: Article
Language:English
Subjects:
Animals
Autophagy
Cytological Techniques
Humans
Phagosomes - metabolism
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Summary:Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate the process of autophagy. However, as autophagy involves dynamic and complicated processes, it is often analyzed incorrectly. In this Primer, we discuss methods to monitor autophagy and to modulate autophagic activity, with a primary focus on mammalian macroautophagy.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2010.01.028