Fresh Osteochondral Allografting for Steroid-associated Osteonecrosis of the Femoral Condyles

• Published in: Clinical orthopaedics and related research 2010-05, Vol.468 (5), p.1269-1278
• Main Authors: Görtz, Simon, De Young, Allison J., Bugbee, William D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Arthroplasty - methods; Bone Transplantation - methods; Chondrocytes - transplantation; Clinical Research; Conservative Orthopedics; Female; Femur - transplantation; Follow-Up Studies; Glucocorticoids - adverse effects; Graft Survival; Humans; Knee; Knee Joint - diagnostic imaging; Knee Joint - physiopathology; Knee Joint - surgery; Male; Medicine; Medicine & Public Health; Orthopedics; Osteonecrosis - chemically induced; Osteonecrosis - diagnosis; Osteonecrosis - surgery; Radiography; Range of Motion, Articular; Retrospective Studies; Sports Medicine; Surgery; Surgical Orthopedics; Time Factors; Transplantation, Homologous; Treatment Outcome; Young Adult
• ISSN: 0009-921X; 1528-1132
• DOI: 10.1007/s11999-010-1250-7

Background Osteonecrosis is a complication of corticosteroid therapy with limited treatment options in young, active patients. These options include debridement, core decompression, osteotomy, allografting, and partial or total knee replacement. Few studies exist regarding the use of osteochondral allografts for treatment of steroid-associated osteonecrosis. Questions/purposes We asked if fresh osteochondral allografts would (1) heal to host bone in the presence of osteonecrosis, (2) provide a clinically meaningful decrease in pain and improvement in function, and (3) prevent or postpone the need for prosthetic arthroplasty. Patients and Methods Twenty-two patients (28 knees) who underwent osteochondral allografting for high-grade, corticosteroid-associated osteonecrosis were evaluated. Their average age was 24.3 years (range, 16–44 years). The mean graft surface area was 10.8 cm 2 (range, 5.0–19.0 cm 2 ). Evaluation included a modified (for the knee) D’Aubigné and Postel (18-point) score, International Knee Documentation Committee (IKDC), and Knee Society function scores. The minimum followup was 25 months (mean, 67 months; range, 25–235 months). Results Five knees failed. The graft survival rate was 89% (25 of 28). The mean D’Aubigné and Postel score improved from 11.3 to 15.8; 19 of 25 (76%) had a score greater than 15. The mean IKDC pain score improved from 7.1 to 2.0, mean IKDC function score from 3.5 to 8.3, and mean Knee Society function score from 60.0 to 85.7. Conclusions Our data suggest osteochondral allografting is a reasonable salvage option for osteonecrosis of the femoral condyles. TKA was avoided in 27 of the 28 of knees at last followup. Level of Evidence Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.