High CO2 /H+ dialysis in the caudal ventrolateral medulla (Loeschcke's area) increases ventilation in wakefulness

Abstract Central chemoreception, the detection of CO2 /H+ within the brain and the resultant effect on ventilation, was initially localized at two areas on the ventrolateral medulla, one rostral (rVLM-Mitchell's) the other caudal (cVLM-Loeschcke's), by surface application of acidic solutio...

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Published in:Respiratory physiology & neurobiology 2010-04, Vol.171 (1), p.46-53
Main Authors: da Silva, Glauber S.F, Li, Aihua, Nattie, Eugene
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Body Temperature - drug effects
Body Temperature - physiology
Carbon Dioxide - administration & dosage
Carbon Dioxide - pharmacology
Dialysis - methods
Electroencephalography - methods
Electromyography - methods
Fundamental and applied biological sciences. Psychology
Hydrogen - administration & dosage
Hydrogen - pharmacology
Male
Medical Education
Medulla Oblongata - drug effects
Oxygen Consumption - drug effects
Oxygen Consumption - physiology
Pulmonary Ventilation - drug effects
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Rats
Rats, Sprague-Dawley
Vertebrates: respiratory system
Wakefulness - drug effects
Wakefulness - physiology
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Summary:Abstract Central chemoreception, the detection of CO2 /H+ within the brain and the resultant effect on ventilation, was initially localized at two areas on the ventrolateral medulla, one rostral (rVLM-Mitchell's) the other caudal (cVLM-Loeschcke's), by surface application of acidic solutions in anesthetized animals. Focal dialysis of a high CO2 /H+ artificial cerebrospinal fluid (aCSF) that produced a milder local pH change in unanesthetized rats (like that with a ∼6.6 mm Hg increase in arterial P C O 2 ) delineated putative chemoreceptor regions for the rVLM at the retrotrapezoid nucleus and the rostral medullary raphe that function predominantly in wakefulness and sleep, respectively. Here we ask if chemoreception in the cVLM can be detected by mild focal stimulation and if it functions in a state dependent manner. At responsive sites just beneath Loeschcke's area, ventilation was increased by, on average, 17% ( P < 0.01) only in wakefulness. These data support our hypothesis that central chemoreception is a distributed property with some sites functioning in a state dependent manner.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2010.01.014