Proteome of Human Minor Salivary Gland Secretion

Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might hypothesize that the proteome of minor gland secretions may show significantly different characteristics when compared with the proteomes of parotid or...

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Bibliographic Details
Published in:Journal of dental research 2008-05, Vol.87 (5), p.445-450
Main Authors: Siqueira, W.L., Salih, E., Wan, D.L., Helmerhorst, E.J., Oppenheim, F.G.
Format: Article
Language:English
Subjects:
Adult
Dentistry
Female
Humans
Male
Proteome - analysis
Proteomics - methods
Reference Values
Salivary Glands, Minor - metabolism
Salivary Glands, Minor - secretion
Salivary Proteins and Peptides - analysis
Salivary Proteins and Peptides - classification
Salivary Proteins and Peptides - metabolism
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Summary:Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might hypothesize that the proteome of minor gland secretions may show significantly different characteristics when compared with the proteomes of parotid or submandibular/sublingual secretions. To test this hypothesis, we conducted the first exploration into the proteome of minor salivary gland secretion. Minor gland secretion was obtained from healthy volunteers, and its components were subjected to liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry. This led to the identification of 56 proteins, 12 of which had never been identified in any salivary secretion. The unique characteristics of the minor salivary gland secretion proteome are related to the types as well as the numbers of components present. The differences between salivary proteomes may be important with respect to specific oral functions.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910808700508