Cytokine Networks in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease more prominent in women and characterized by multiple organ damage. Imbalance in cytokine production and cytokine levels correlates with SLE progression, making the understanding of SLE cytokine networks very important for SLE treatment str...

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Bibliographic Details
Published in:BioMed research international 2010-01, Vol.2010 (2010), p.1-5
Main Authors: Lee, Hooi-Ming, Sugino, Hidehiko, Nishimoto, Norihiro
Format: Article
Language:English
Subjects:
Autoimmune diseases
Cytokines - immunology
Cytokines - metabolism
Estrogens - metabolism
Female
Humans
Immune system
Immunology
Lupus
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - metabolism
Male
Review
Signal Transduction
Womens health
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Summary:Systemic lupus erythematosus (SLE) is an autoimmune disease more prominent in women and characterized by multiple organ damage. Imbalance in cytokine production and cytokine levels correlates with SLE progression, making the understanding of SLE cytokine networks very important for SLE treatment strategy and drug development. In this article, we review cytokine networks that may be involved in the pathogenesis of SLE by briefly describing abnormal cytokine production and serum cytokine levels in SLE patients. We also focus on the pathological roles of cytokines and their interactions in immunoregulatory networks and suggest how their disturbances may implicate in pathological conditions in SLE. Finally, we further discuss the influence of estrogen on these cytokine networks.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/676284