Molecular Structure of Sarcomere-to-Membrane Attachment at M-Lines in C. elegans Muscle

C. elegans is an excellent model for studying nonmuscle cell focal adhesions and the analogous muscle cell attachment structures. In the major striated muscle of this nematode, all of the M-lines and the Z-disk analogs (dense bodies) are attached to the muscle cell membrane and underlying extracellu...

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Bibliographic Details
Published in:BioMed research international 2010-01, Vol.2010 (2010), p.1-9
Main Authors: Qadota, Hiroshi, Benian, Guy M.
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Caenorhabditis elegans - chemistry
Caenorhabditis elegans - cytology
Caenorhabditis elegans - metabolism
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - physiology
Carrier Proteins - physiology
Focal Adhesions - physiology
Genetics
Genotype & phenotype
Integrins - physiology
Muscle Proteins - physiology
Muscles - chemistry
Muscles - cytology
Muscles - metabolism
Muscles - physiology
Muscular system
Mutation
Nematoda
Proteins
Review
Sarcomeres - chemistry
Sarcomeres - physiology
Sarcomeres - ultrastructure
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Summary:C. elegans is an excellent model for studying nonmuscle cell focal adhesions and the analogous muscle cell attachment structures. In the major striated muscle of this nematode, all of the M-lines and the Z-disk analogs (dense bodies) are attached to the muscle cell membrane and underlying extracellular matrix. Accumulating at these sites are many proteins associated with integrin. We have found that nematode M-lines contain a set of protein complexes that link integrin-associated proteins to myosin thick filaments. We have also obtained evidence for intriguing additional functions for these muscle cell attachment proteins.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/864749