Arterial Destiffening With Weight Loss in Overweight and Obese Middle-Aged and Older Adults

We tested the hypothesis that weight loss via a hypocaloric diet would reduce arterial stiffness in overweight and obese middle-aged and older adults. Thirty-six individuals were randomly assigned to a weight loss (n=25; age61.2±0.8 years; body mass index30.0±0.6 kg/m) or a control (n=11; age66.1±1....

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-04, Vol.55 (4), p.855-861
Main Authors: Dengo, A Laura, Dennis, Elizabeth A, Orr, Jeb S, Marinik, Elaina L, Ehrlich, Elizabeth, Davy, Brenda M, Davy, Kevin P
Format: Article
Language:English
Subjects:
Adiposity - physiology
Aged
Analysis of Variance
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Body Composition - physiology
Body Mass Index
Cardiology. Vascular system
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - physiopathology
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Chi-Square Distribution
Female
Humans
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - diagnostic imaging
Obesity - physiopathology
Overweight - diagnostic imaging
Overweight - physiopathology
Pulsatile Flow - physiology
Regression Analysis
Ultrasonography
Weight Loss - physiology
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Summary:We tested the hypothesis that weight loss via a hypocaloric diet would reduce arterial stiffness in overweight and obese middle-aged and older adults. Thirty-six individuals were randomly assigned to a weight loss (n=25; age61.2±0.8 years; body mass index30.0±0.6 kg/m) or a control (n=11; age66.1±1.9 years; body mass index31.8±1.4 kg/m) group. Arterial stiffness was measured via carotid artery ultrasonography combined with applanation tonometry and carotid-femoral pulse wave velocity via applanation tonometry at baseline and after the 12-week intervention. Body weight, body fat, abdominal adiposity, blood pressure, β-stiffness index, and carotid-femoral pulse wave velocity were similar in the 2 groups at baseline (all P>0.05). Body weight (−7.1±0.7 versus −0.7±1.1 kg), body fat, and abdominal adiposity decreased in the weight loss group but not in the control group (all P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.109.147850