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Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia
Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyt...
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| Published in: | Acta tropica 2010-04, Vol.114 (1), p.17-21 |
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| container_title | Acta tropica |
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| creator | Caicedo, Olga Villamor, Eduardo Forero, Yibby Ziade, José Pérez, Pilar Quiñones, Francisco Arévalo-Herrera, Myriam Herrera, Sócrates |
| description | Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly
Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies was 26.0 and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1
g/dL (
p
=
0.04;
p, test for trend
=
0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia. |
| doi_str_mv | 10.1016/j.actatropica.2009.11.005 |
| format | article |
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Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies was 26.0 and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1
g/dL (
p
=
0.04;
p, test for trend
=
0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2009.11.005</identifier><identifier>PMID: 19931503</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Anemia ; Anemia - epidemiology ; Anemias. Hemoglobinopathies ; Animals ; Biological and medical sciences ; Colombia ; Cross-Sectional Studies ; Diseases of red blood cells ; Female ; Folic Acid - analysis ; General aspects ; Hematologic and hematopoietic diseases ; Hemoglobins - analysis ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Malaria, Falciparum - complications ; Malaria, Falciparum - pathology ; Male ; Medical sciences ; Middle Aged ; Parasitemia ; Parasitic diseases ; Plasmodium falciparum ; Plasmodium falciparum - isolation & purification ; Protozoal diseases ; Vitamin B 12 - analysis ; Young Adult</subject><ispartof>Acta tropica, 2010-04, Vol.114 (1), p.17-21</ispartof><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-fa6be80f53fdbfc96030732107a06982b2a98f14dc9c741b1d916169bdeab3e43</citedby><cites>FETCH-LOGICAL-c544t-fa6be80f53fdbfc96030732107a06982b2a98f14dc9c741b1d916169bdeab3e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22520629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19931503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caicedo, Olga</creatorcontrib><creatorcontrib>Villamor, Eduardo</creatorcontrib><creatorcontrib>Forero, Yibby</creatorcontrib><creatorcontrib>Ziade, José</creatorcontrib><creatorcontrib>Pérez, Pilar</creatorcontrib><creatorcontrib>Quiñones, Francisco</creatorcontrib><creatorcontrib>Arévalo-Herrera, Myriam</creatorcontrib><creatorcontrib>Herrera, Sócrates</creatorcontrib><title>Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly
Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies was 26.0 and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1
g/dL (
p
=
0.04;
p, test for trend
=
0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia</subject><subject>Anemia - epidemiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colombia</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Folic Acid - analysis</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins - analysis</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitemia</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Protozoal diseases</subject><subject>Vitamin B 12 - analysis</subject><subject>Young Adult</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkV2r1DAQhosonvXoX5B6Id7Ymo822dwIuvgFBwRR8C5M0umeLG2yJu2K_8CfbWqX4_FKr5LMPPPOTN6ieEJJTQkVLw412AmmGI7OQs0IUTWlNSHtnWJDt5JXgrXN3WJDCKGVJOLrRfEgpUN-Mdmy-8UFVYrTlvBN8fMTDjC54EuD03dEX57cBKPz5WvKSvBd2YcMYJlywzk9_x26xjHsh2AyZYO36Ke4aizJI0RIbsLRQdnN0fl9CXbOCiMMEHPQ-R7tgqd8LXdhCKNx8LC418OQ8NH5vCy-vH3zefe-uvr47sPu1VVl26aZqh6EwS3pW953prdKEE4kZ5RIIEJtmWGgtj1tOqusbKihnaKCCmU6BMOx4ZfFy1X3OJsRu3X4QR-jGyH-0AGc_jvj3bXeh5Nm26UXyQLPzgIxfJsxTXp0yeIwgMcwJy0bQaSkbfNvknMhleRtJtVK2hhSitjfzEOJXizXB33Lcr1YrinV2fJc-_j2Qn8qzx5n4OkZgGRh6CN469INx1jLiGAqc7uVw_z9J4dRJ-sw29u5mA3TXXD_Mc4v-lnTyg</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Caicedo, Olga</creator><creator>Villamor, Eduardo</creator><creator>Forero, Yibby</creator><creator>Ziade, José</creator><creator>Pérez, Pilar</creator><creator>Quiñones, Francisco</creator><creator>Arévalo-Herrera, Myriam</creator><creator>Herrera, Sócrates</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20100401</creationdate><title>Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia</title><author>Caicedo, Olga ; Villamor, Eduardo ; Forero, Yibby ; Ziade, José ; Pérez, Pilar ; Quiñones, Francisco ; Arévalo-Herrera, Myriam ; Herrera, Sócrates</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-fa6be80f53fdbfc96030732107a06982b2a98f14dc9c741b1d916169bdeab3e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia</topic><topic>Anemia - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colombia</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Folic Acid - analysis</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins - analysis</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - complications</topic><topic>Malaria, Falciparum - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitemia</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - isolation & purification</topic><topic>Protozoal diseases</topic><topic>Vitamin B 12 - analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caicedo, Olga</creatorcontrib><creatorcontrib>Villamor, Eduardo</creatorcontrib><creatorcontrib>Forero, Yibby</creatorcontrib><creatorcontrib>Ziade, José</creatorcontrib><creatorcontrib>Pérez, Pilar</creatorcontrib><creatorcontrib>Quiñones, Francisco</creatorcontrib><creatorcontrib>Arévalo-Herrera, Myriam</creatorcontrib><creatorcontrib>Herrera, Sócrates</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caicedo, Olga</au><au>Villamor, Eduardo</au><au>Forero, Yibby</au><au>Ziade, José</au><au>Pérez, Pilar</au><au>Quiñones, Francisco</au><au>Arévalo-Herrera, Myriam</au><au>Herrera, Sócrates</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>114</volume><issue>1</issue><spage>17</spage><epage>21</epage><pages>17-21</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly
Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies was 26.0 and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1
g/dL (
p
=
0.04;
p, test for trend
=
0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>19931503</pmid><doi>10.1016/j.actatropica.2009.11.005</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta tropica, 2010-04, Vol.114 (1), p.17-21 |
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| source | ScienceDirect Journals |
| subjects | Adolescent Adult Anemia Anemia - epidemiology Anemias. Hemoglobinopathies Animals Biological and medical sciences Colombia Cross-Sectional Studies Diseases of red blood cells Female Folic Acid - analysis General aspects Hematologic and hematopoietic diseases Hemoglobins - analysis Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - complications Malaria, Falciparum - pathology Male Medical sciences Middle Aged Parasitemia Parasitic diseases Plasmodium falciparum Plasmodium falciparum - isolation & purification Protozoal diseases Vitamin B 12 - analysis Young Adult |
| title | Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia |
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