A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese

• Published in: Acta pharmacologica Sinica 2010-04, Vol.31 (4), p.450-454
• Main Authors: Qin, Wen, Zhang, Rong, Hu, Cheng, Wang, Cong-rong, Lu, Jing-yi, Yu, Wei-hui, Bao, Yu-qian, Xiang, Kun-san, Jia, Wei-ping
• Format: Article
• Language: English
• Subjects: 2型糖尿病; Adaptor Proteins, Signal Transducing - genetics; Biomedical and Life Sciences; Biomedicine; Carbamates - pharmacology; Carbamates - therapeutic use; China - ethnology; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - genetics; Female; Humans; Hypoglycemic Agents - therapeutic use; Immunology; Insulin resistance; Insulin Resistance - ethnology; Insulin Resistance - genetics; Internal Medicine; Male; Medical Microbiology; Middle Aged; Original; original-article; Pharmacology/Toxicology; Piperidines - pharmacology; Piperidines - therapeutic use; Polymorphism, Single Nucleotide; Vaccine; 一氧化氮合酶; 单核苷酸多态性; 基因变异; 实验室测试; 胰岛素分泌; 胰岛素抵抗
• ISSN: 1671-4083; 1745-7254
• DOI: 10.1038/aps.2010.25

Aim： To investigate a potential association between SNP rs 10494366 in the neural nitric oxide synthase adaptor protein （NOS1AP） and efficacy of repaglinide （an insulin secretagogue） in newly diagnosed Shanghai Chinese type 2 diabetes patients. Methods： A total of 104 newly diagnosed type 2 diabetes patients （69 men, 35 women） were recruited and treated with repaglinide for 24 weeks. Anthropometric measurements, clinical laboratory tests were obtained at baseline and after 24-week treatment. Genotyping was performed by sequencing. Results： The baseline value of BMI, HOMA-IR, HOMA-B, and fasting insulin level were significantly different between GG, GT, and TT genotypes （P=0.024, 0.030, 0.005, and 0.007, respectively）. Carriers of TT genotype were in significant insulin resistance at baseline. After 24-week repaglinide monotherapy, the Δ value of fasting insulin （P=0.019） and HOMA-IR （P=0.011） were significantly different. TT carriers had the least insulin resistance after treatment. The mixed model analysis showed that the variation had an interaction effect with repaglinide treatment only on HOMA-IR （P=0.013）. Conclusion： A common variant in rs10494366 is associated with repaglinide monotherapy efficacy on insulin resistance in newly diagnosed Shanghai Chinese type 2 diabetes patients.