NF-κB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS

Abstract In this study, the role of NF-κB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-κB1−/− mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated wi...

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Bibliographic Details
Published in:Journal of neuroimmunology 2010-05, Vol.222 (1), p.19-28
Main Authors: Harris, Tajie H, Wilson, Emma H, Tait, Elia D, Buckley, Marie, Shapira, Sagi, Caamano, Jorge, Artis, David, Hunter, Christopher A
Format: Article
Language:English
Subjects:
Accessory cells
Allergy and Immunology
CD8 + T cell
Neurology
NF-κB
Toxoplasma gondii
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Summary:Abstract In this study, the role of NF-κB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-κB1−/− mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8+ T cells and IFN-γ production, while accessory cell function appeared intact in NF-κB1−/− mice. Consistent with these findings, T cell transfer studies revealed that NF-κB1−/− T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-κB1 in T cell-mediated immunity to Toxoplasma gondii.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2009.12.009