Trafficking of immune cells in the central nervous system

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with th...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 2010-05, Vol.120 (5), p.1368-1379
Main Authors: Wilson, Emma H, Weninger, Wolfgang, Hunter, Christopher A
Format: Article
Language:English
Subjects:
Animals
Astrocytes - cytology
Biomedical research
Brain
Brain - physiology
Care and treatment
Cell Adhesion
Cell Movement
Central nervous system
Central Nervous System - immunology
Cerebrospinal fluid
Chemokines - metabolism
Development and progression
Disease
Encephalitis
Humans
Immune system
Immune System - physiology
Immunity
Infections
Inflammation
Kinetics
Lymphocytes
Lymphocytes - cytology
Medical examination
Meningitis
Models, Biological
Pathogens
Properties
Science in Medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci41911