ABBA family of aromatic prenyltransferases: broadening natural product diversity

An analysis of the ABBA family of aromatic prenyltransferases was conducted. further structural and biochemical characterization of additional members of the ABBA family of aromatic PTases, such as the novel fungal members, will afford a more complete understanding of the key features involved in su...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2008-05, Vol.65 (10), p.1459-1463
Main Authors: Tello, M, Kuzuyama, T, Heide, L, Noel, J. P, Richard, S. B
Format: Article
Language:English
Subjects:
Amino Acids, Aromatic - metabolism
antibacterial
Aromatic
Bacterial Proteins - metabolism
Bacterial Proteins - physiology
Biochemistry
Biodiversity
Biological Products - physiology
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Biotechnology
Cell Biology
chemoprotection
Dimethylallyltranstransferase - chemistry
Dimethylallyltranstransferase - metabolism
Dimethylallyltranstransferase - physiology
Enzymes
isoprenoids
Life Sciences
Models, Biological
Models, Molecular
Multigene Family
Natural products
Pharmacology
Phylogeny
prenyltransferase
Protein Conformation
Protein Engineering - methods
PT-barrel
regio-selective
Substrates
Visions & Reflections (Minireview)
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Summary:An analysis of the ABBA family of aromatic prenyltransferases was conducted. further structural and biochemical characterization of additional members of the ABBA family of aromatic PTases, such as the novel fungal members, will afford a more complete understanding of the key features involved in substrate selection and specificity/promiscuity.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-008-7579-3