Fluorescent Nano-Optodes for Glucose Detection

We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2010-05, Vol.82 (9), p.3707-3713
Main Authors: Billingsley, Kelvin, Balaconis, Mary K, Dubach, J. Matthew, Zhang, Ning, Lim, Ed, Francis, Kevin P, Clark, Heather A
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Biosensing Techniques
Blood Glucose - analysis
Blood Glucose - chemistry
Boronic Acids - chemistry
Chemistry
Diabetes
Exact sciences and technology
Fluorescent Dyes
General, instrumentation
Glucose
Glucose - analysis
Measurement
Mice
Molecular Structure
Molecules
Nanotechnology
Rodents
Sensors
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Summary:We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated this response in vitro and also when injected subcutaneously into mice. The response of the nanosensors tracked changes in blood glucose levels in vivo that were comparable to measurements taken using a glucometer. The development of these nanosensors offers an alternative, minimally invasive tool for monitoring glucose levels in such fields as diabetes research. Furthermore, the extension of the ion-selective optode sensor platform to small molecule detection will allow for enhanced monitoring of physiological processes.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac100042e