Bioactive Constituents of the Stem Bark of Mitrephora glabra

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2009-11, Vol.72 (11), p.1949-1953
• Main Authors: Li, Chen, Lee, Dongho, Graf, Tyler N, Phifer, Sharnelle S, Nakanishi, Yuka, Riswan, Soedarsono, Setyowati, Fransisca M, Saribi, Achmad M, Soejarto, Djaja D, Farnsworth, Norman R, Falkinham, III, Joseph O, Kroll, David J, Kinghorn, A. Douglas, Wani, Mansukh C, Oberlies, Nicholas H
• Format: Article
• Language: English
• Subjects: 4-epi-kaurenic acid; 9,10-dihydrooropheolide; Annonaceae; Annonaceae - chemistry; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; antibacterial properties; anticarcinogenic activity; antifungal properties; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Aporphines - isolation & purification; Aspergillus niger - drug effects; Biological and medical sciences; chemical constituents of plants; chemical structure; cytotoxicity; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Drug Screening Assays, Antitumor; Female; General pharmacology; human diseases; human health; Humans; Indonesia; liriodenine; Medical sciences; medicinal properties; methylmitrekaurenate; methyloropheate; Microbial Sensitivity Tests; Micrococcus luteus - drug effects; mitrekaurenone; Mitrephora glabra; mitrephorenone; Molecular Structure; Mycobacterium - drug effects; Nuclear Magnetic Resonance, Biomolecular; octadeca-9,11,13-triynoic acid; oropheolide; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Bark - chemistry; Plants, Medicinal - chemistry; Polyacetylenes - chemistry; Polyacetylenes - isolation & purification; Polyacetylenes - pharmacology; polyacetylenic acid; Saccharomyces cerevisiae - drug effects; spectral analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np900572g

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1−3), five polyacetylenic acids/esters (4−8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1−3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.