Application of Adoptive T-Cell Therapy Using Tumor Antigen-Specific T-Cell Receptor Gene Transfer for the Treatment of Human Leukemia

The last decade has seen great strides in the field of cancer immunotherapy, especially the treatment of melanoma. Beginning with the identification of cancer antigens, followed by the clinical application of anti-cancer peptide vaccination, it has now been proven that adoptive T-cell therapy (ACT)...

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Bibliographic Details
Published in:BioMed research international 2010-01, Vol.2010 (2010), p.1-10
Main Authors: Ochi, Toshiki, Fujiwara, Hiroshi, Yasukawa, Masaki
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - immunology
Cancer
Cancer therapies
Clinical medicine
Clinical trials
Gene therapy
Gene Transfer Techniques
Genetic Therapy
Humans
Immunization
Immunology
Immunotherapy, Adoptive - methods
Leukemia - genetics
Leukemia - immunology
Leukemia - therapy
Peptides
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - therapeutic use
Review
Studies
T-Lymphocytes - immunology
Tumors
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Summary:The last decade has seen great strides in the field of cancer immunotherapy, especially the treatment of melanoma. Beginning with the identification of cancer antigens, followed by the clinical application of anti-cancer peptide vaccination, it has now been proven that adoptive T-cell therapy (ACT) using cancer antigen-specific T cells is the most effective option. Despite the apparent clinical efficacy of ACT, the timely preparation of a sufficient number of cancer antigen-specific T cells for each patient has been recognized as its biggest limitation. Currently, therefore, attention is being focused on ACT with engineered T cells produced using cancer antigen-specific T-cell receptor (TCR) gene transfer. With regard to human leukemia, ACT using engineered T cells bearing the leukemia antigen-specific TCR gene still remains in its infancy. However, several reports have provided preclinical data on TCR gene transfer using Wilms' tumor gene product 1 (WT1), and also preclinical and clinical data on TCR gene transfer involving minor histocompatibility antigen, both of which have been suggested to provide additional clinical benefit. In this review, we examine the current status of anti-leukemia ACT with engineered T cells carrying the leukemia antigen-specific TCR gene, and discuss the existing barriers to progress in this area.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/521248