Multidrug-Resistance Gene (P-glycoprotein) is Expressed by Endothelial Cells at Blood--Brain Barrier Sites

Endothelial cells of human capillary blood vessels at the blood--brain and other blood--tissue barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against the human multidrug-resistance gene product. This pattern of endothelial cell expression may indicate a physiological...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1989-01, Vol.86 (2), p.695-698
Main Authors: Cordon-Cardo, Carlos, O'Brien, James P., Casals, Dolors, Rittman-Grauer, Lana, Biedler, June L., Melamed, Myron R., Bertino, Joseph R.
Format: Article
Language:English
Subjects:
550400 - Genetics
ANIMAL TISSUES
ANIMALS
ANTIBODIES
ATP Binding Cassette Transporter, Subfamily B, Member 1
BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
Biological and medical sciences
Blood vessels
BLOOD-BRAIN BARRIER
Blood-Testis Barrier
BODY
BRAIN
Capillaries
Cell lines
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CHEMOTHERAPY
CYTOCHEMISTRY
Drug Resistance - genetics
drugs
Endothelial cells
ENDOTHELIUM
Endothelium, Vascular - analysis
Epithelial cells
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation
GENE REGULATION
genes
GLYCOPROTEINS
GONADS
Humans
Immunohistochemistry
MALE GENITALS
MAMMALS
MAN
Melanoma
Membrane Glycoproteins - analysis
Membrane Glycoproteins - biosynthesis
Membrane Glycoproteins - genetics
Molecular and cellular biology
Molecular genetics
MONOCLONAL ANTIBODIES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
Papillae
PRIMATES
PROTEINS
SENSITIVITY
SKIN
TESTES
THERAPY
TISSUES
Transfection
Tumor Cells, Cultured
VERTEBRATES
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Description
Summary:Endothelial cells of human capillary blood vessels at the blood--brain and other blood--tissue barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against the human multidrug-resistance gene product. This pattern of endothelial cell expression may indicate a physiological role for P-glycoprotein in regulating the entry of certain molecules into the central nervous system and other anatomic compartments, such as the testes. These tissues, which limit the access of systemic drugs, are known pharmacologic sanctuaries for metastatic cancer. P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.86.2.695