Senescent cells as a source of inflammatory factors for tumor progression

Cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive mechanism. Recent studies show that, despite the beneficial effects of cellular senescence, senescent cells can also exert...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2010-06, Vol.29 (2), p.273-283
Main Authors: Davalos, Albert R., Coppe, Jean-Philippe, Campisi, Judith, Desprez, Pierre-Yves
Format: Article
Language:English
Subjects:
Aging
Animals
BASIC BIOLOGICAL SCIENCES
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Cancer. Inflammation
Cellular Senescence - physiology
Cytokines
Cytokines - metabolism
Development and progression
Disease Progression
Disease susceptibility
Humans
Inflammation - immunology
Inflammation - metabolism
Interleukins
Invasion
Migration
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Oncology
Proliferation
Senescence
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Summary:Cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive mechanism. Recent studies show that, despite the beneficial effects of cellular senescence, senescent cells can also exert harmful effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescent-associated secretory phenotype (SASP), which entails a striking increase in the secretion of pro-inflammatory cytokines. Here, we summarize our knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression.
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-010-9220-9