Simultaneous RP-HPLC Estimation of Trifluoperazine Hydrochloride and Chlordiazepoxide in Tablet Dosage Forms

A binary mixture of trifluoperazine HCl and chlordiazepoxide was determined using reversed-phase liquid chromatography method using methanol:water (97:03, v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 262 nm over concentration ranges of 0.1-1 and...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2009-09, Vol.71 (5), p.545-547
Main Authors: Patel, Sejal K, Patel, N J
Format: Article
Language:English
Subjects:
Analytical chemistry
Chlordiazepoxide hydrochloride
Chromatography
High performance liquid chromatography
Measurement
Methods
Pharmaceuticals
Short Communications
Trifluoperazine
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Summary:A binary mixture of trifluoperazine HCl and chlordiazepoxide was determined using reversed-phase liquid chromatography method using methanol:water (97:03, v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 262 nm over concentration ranges of 0.1-1 and 0.5-5 mug/ml; mean accuracies were 101.05+/-0.47 and 98.97+/-0.33 %, respectively. The method was successively applied to tablet dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.58192