[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in the mouse brain

Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH 2 ) and the structurally related [Glu 2 ]TRH (pGlu-Glu-Pro-NH 2 ) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu 2 ]TRH, although the involvemen...

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Bibliographic Details
Published in:Brain research bulletin 2010-02, Vol.82 (1-2), p.83-86
Main Authors: Nguyen, Vien, Zharikova, Alevtina D., Prokai-Tatrai, Katalin, Prokai, Laszlo
Format: Article
Language:English
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Summary:Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH 2 ) and the structurally related [Glu 2 ]TRH (pGlu-Glu-Pro-NH 2 ) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu 2 ]TRH, although the involvement of different receptors are presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu 2 ]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-depended attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu 2 ]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu 2 ]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2010.02.007