Noninvasive Imaging of Angiotensin Receptors After Myocardial Infarction

• Published in: JACC. Cardiovascular imaging 2008-05, Vol.1 (3), p.354-362
• Main Authors: Verjans, Johan W.H., MD, Lovhaug, Dagfinn, PhD, Narula, Navneet, MD, Petrov, Artiom D., PhD, Indrevoll, Bård, MS, Bjurgert, Emma, PhD, Krasieva, Tatiana B., PhD, Petersen, Lizette B., MS, Kindberg, Grete M., PhD, Solbakken, Magne, PhD, Cuthbertson, Alan, PhD, Vannan, Mani A., MD, FACC, Reutelingsperger, Chris P.M., PhD, Tromberg, Bruce J., PhD, Hofstra, Leonard, MD, PhD, Narula, Jagat, MD, PhD, FACC
• Format: Article
• Language: English
• Subjects: Angiotensin II - analogs & derivatives; Angiotensin II - metabolism; Angiotensin II Type 1 Receptor Blockers - metabolism; Animals; Binding Sites; Biomarkers - metabolism; Cardiovascular; Disease Models, Animal; Feasibility Studies; Fluorescent Dyes - metabolism; Heart Failure - diagnostic imaging; Heart Failure - etiology; Heart Failure - metabolism; Heart Failure - physiopathology; Losartan - metabolism; Male; Mice; Microscopy, Confocal; Microscopy, Fluorescence - methods; Microscopy, Fluorescence, Multiphoton; Microscopy, Video; Myocardial Infarction - complications; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - metabolism; Myocardial Infarction - physiopathology; Myocardium - metabolism; Myocardium - pathology; Radiopharmaceuticals - metabolism; Receptors, Angiotensin - metabolism; Technetium; Time Factors; Tomography, Emission-Computed, Single-Photon - methods; Ventricular Remodeling; X-Ray Microtomography
• ISSN: 1936-878X; 1876-7591
• DOI: 10.1016/j.jcmg.2007.11.007

Noninvasive Imaging of Angiotensin Receptors After Myocardial Infarction Johan W. H. Verjans, Dagfinn Lovhaug, Navneet Narula, Artiom D. Petrov, Bård Indrevoll, Emma Bjurgert, Tatiana B. Krasieva, Lizette B. Petersen, Grete M. Kindberg, Magne Solbakken, Alan Cuthbertson, Mani A. Vannan, Chris P. M. Reutelingsperger, Bruce J. Tromberg, Leonard Hofstra, Jagat Narula Tissue upregulation of various neurohormonal cascades is known to play an important role in post-myocardial infarction remodeling. It is expected that an imaging strategy designed to target angiotensin receptors may predict the likelihood of remodeling and, hence, heart failure. Using fluorescent and radiolabeled angiotensin peptide analog or losartan, the present study demonstrated the feasibility of noninvasive imaging of angiotensin type-1 receptor upregulation. The uptake of angiotensin peptide was traced to collagen-producing myofibroblasts in the healing infarct zone. If proved clinically, such a strategy may identify patients at risk of developing heart failure and allow demonstration of efficacy of pharmacologic intervention in patients with overt and covert heart failure.