Host adapted serotypes of Salmonella enterica

• Published in: Epidemiology and infection 2000-10, Vol.125 (2), p.229-255
• Main Authors: UZZAU, S., BROWN, D. J., WALLIS, T., RUBINO, S., LEORI, G., BERNARD, S., CASADESÚS, J., PLATT, D. J., OLSEN, J. E.
• Format: Article
• Language: English
• Subjects: Abortion, Septic - microbiology; Abortion, Septic - pathology; Animal bacterial diseases; Bacteria; Bacterial diseases; Bacteriology; Biological and medical sciences; Enteritis - microbiology; Enteritis - pathology; Epidemiology; Epithelial cells; Female; Fundamental and applied biological sciences. Psychology; Humans; Infections; Infectious diseases; Macrophages; Male; Medical sciences; Microbiology; Plasmids; Pregnancy; REVIEW; Salmonella; Salmonella enterica - classification; Salmonella enterica - pathogenicity; Salmonella infections; Salmonella Infections - pathology; Salmonella typhi; Salmonella typhimurium; Sepsis - microbiology; Sepsis - pathology; Serotyping; Virulence
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/s0950268899004379

Salmonella constitutes a genus of zoonotic bacteria of worldwide economic and health importance. The current view of salmonella taxonomy assigns the members of this genus to two species: S. enterica and S. bongori. S. enterica itself is divided into six subspecies, enterica, salamae, arizonae, diarizonae, indica, and houtenae, also known as subspecies I, II, IIIa, IIIb, IV, and VI, respectively [1]. Members of Salmonella enterica subspecies enterica are mainly associated with warm-blooded vertebrates and are usually transmitted by ingestion of food or water contaminated by infected faeces. The pathogenicity of most of the distinct serotypes remains undefined, and even within the most common serotypes, many questions remain to be answered regarding the interactions between the organism and the infected host. Salmonellosis manifests itself in three major forms: enteritis, septicaemia, and abortion, each of which may be present singly or in combination, depending on both the serotype and the host involved. Although currently over 2300 serovars of Salmonella are recognized, only about 50 serotypes are isolated in any significant numbers as human or animal pathogens [2, 3] and they all belong to subspecies enterica. Of these, most cause acute gastroenteritis characterized by a short incubation period and a severe systemic disease in man or animals, characterized by septicaemia, fever and/or abortion, and such serotypes are often associated with one or few host species [4–6]. It is the intention of this review to present a summary of current knowledge of these host-adapted serotypes of S. enterica. The taxonomic relationships between the serotypes will be discussed together with a comparison of the pathology and pathogenesis of the disease that they cause in their natural host(s). Since much of our knowledge on salmonellosis is based on the results of work on Typhimurium, this serotype will often be used as the baseline in discussion. It is hoped that an appreciation of the differences that exist in the way these serotypes interact with the host will lead to a greater understanding of the complex host–parasite relationship that characterizes salmonella infections.