Risk factors for infection with Campylobacter jejuni flaA genotypes

We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing (flaA genotyping). Exposure information for cases and controls was...

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Bibliographic Details
Published in:Epidemiology and infection 2008-11, Vol.136 (11), p.1480-1491
Main Authors: UNICOMB, L. E., O'REILLY, L. C., KIRK, M. D., STAFFORD, R. J., SMITH, H. V., BECKER, N. G., PATEL, M. S., GILBERT, G. L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antacids
Australia - epidemiology
Bacterial Typing Techniques
Biological and medical sciences
Campylobacter
Campylobacter Infections - epidemiology
Campylobacter jejuni - classification
Campylobacter jejuni - genetics
Campylobacter jejuni - isolation & purification
Case-Control Studies
Child
Child, Preschool
Diarrhea
DNA Fingerprinting
DNA, Bacterial - genetics
Enzymes
Female
Flagellin - genetics
Fundamental and applied biological sciences. Psychology
Gastroenteritis
Genotype
Households
Humans
Infant
Infant, Newborn
Infections
Interviews
Laboratories
Logistic Models
Male
Meat Products - microbiology
Microbiology
Middle Aged
Multivariate Analysis
Original Papers
Polymorphism, Restriction Fragment Length
Prospective Studies
Questionnaires
Risk Factors
Scandals
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Summary:We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing (flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases – flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268807000246