HIV subtypes in Scotland, 2000–2006

The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data includ...

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Bibliographic Details
Published in:Epidemiology and infection 2008-08, Vol.136 (8), p.1069-1075
Main Authors: YIRRELL, D. L., SHAW, L., CAMPBELL, E., BURNS, S. M., CAMERON, S. O., GOLDBERG, D.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Biological and medical sciences
Disease transmission
Epidemics
Female
Fundamental and applied biological sciences. Psychology
Genes, env - genetics
Genes, gag - genetics
Heterosexuality
HIV
HIV 1
HIV Infections - epidemiology
HIV Infections - transmission
HIV-1 - genetics
Human immunodeficiency virus
Humans
Infections
Male
Men
Microbiology
Miscellaneous
Molecular Epidemiology
Original Papers
Polymerase Chain Reaction
Risk Factors
RNA, Viral - analysis
Scotland - epidemiology
Specimens
Surveillance
Testing laboratories
Virology
Viruses
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Summary:The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268807009545