The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia

Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study pop...

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Bibliographic Details
Published in:Netherlands heart journal 2010-05, Vol.18 (5), p.255-259
Main Authors: Klein, L. J., Visser, F. C.
Format: Article
Language:English
Subjects:
Cardiology
Medical Education
Medicine
Medicine & Public Health
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Review Article
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Summary:Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.).
ISSN:1568-5888
1876-6250
DOI:10.1007/BF03091772