Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 ve...

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Bibliographic Details
Published in:International journal of environmental research and public health 2010-04, Vol.7 (4), p.1366-1378
Main Authors: Balbi, Massimiliano, Donadon, Valter, Ghersetti, Michela, Grazioli, Silvia, Valentina, Giovanni Della, Gardenal, Rita, Mas, Maria Dal, Casarin, Pietro, Zanette, Giorgio, Miranda, Cesare, Cimarosti, Paolo
Format: Article
Language:English
Subjects:
Aged
Alcoholism
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - epidemiology
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Female
Hepatitis
Hepatitis C virus
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - epidemiology
Humans
Italy
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - epidemiology
Liver Neoplasms - complications
Liver Neoplasms - epidemiology
Male
Middle Aged
Prevalence
Risk factors
Tumors
Viruses
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Summary:Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph7041366