Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma

Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeneous group of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia overwhelmingly predominates the AH...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2010-04, Vol.3 (4), p.448-457
Main Authors: Du, Shouying, Rashidi, Hooman H, Le, Dzung T, Kipps, Thomas J, Broome, H Elizabeth, Wang, Huan-You
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Case Report
Cell Separation
DNA Mutational Analysis
Female
Flow Cytometry
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Mastocytosis - complications
Mastocytosis - genetics
Mastocytosis - pathology
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - genetics
Multiple Myeloma - pathology
Proto-Oncogene Proteins c-kit - genetics
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Summary:Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeneous group of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia overwhelmingly predominates the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously.
ISSN:1936-2625