Loading…

Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood

Summary The diagnosis of sideroblastic anemia is based on bone marrow aspiration, and the detection of ring sideroblasts (RS) in iron staining. The finding of laboratory parameters to approach this diagnosis still remains a great challenge. In this study, we analyzed the value of a specific erythrog...

Full description

Saved in:
Bibliographic Details
Published in:International journal of laboratory hematology 2010-06, Vol.32 (3), p.329-335
Main Authors: ROVÓ, A., STÜSSI, G., MEYER-MONARD, S., FAVRE, G., TSAKIRIS, D., HEIM, D., HALTER, J., ARBER, C., PASSWEG, J., GRATWOHL, A., TICHELLI, A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573
cites cdi_FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573
container_end_page 335
container_issue 3
container_start_page 329
container_title International journal of laboratory hematology
container_volume 32
creator ROVÓ, A.
STÜSSI, G.
MEYER-MONARD, S.
FAVRE, G.
TSAKIRIS, D.
HEIM, D.
HALTER, J.
ARBER, C.
PASSWEG, J.
GRATWOHL, A.
TICHELLI, A.
description Summary The diagnosis of sideroblastic anemia is based on bone marrow aspiration, and the detection of ring sideroblasts (RS) in iron staining. The finding of laboratory parameters to approach this diagnosis still remains a great challenge. In this study, we analyzed the value of a specific erythrogram pattern from peripheral blood, produced by the ADVIA®120 cell counter, to predict sideroblastic changes in the bone marrow. In a two step‐design study, we first showed that 32/38 consecutive patients reporting ≥15% RS had such a pattern in the erythrogram. In the second step, we prospectively identified over a period of 32 months 21 patients with this typical erythrogram; 20/21 had ≥15% RS in the bone marrow. Hence, by this validation, we confirm that the erythrogram is highly predictive of RS in the bone marrow. The interpretation of the erythrogram should become daily practice in hematology to improve the efficacy to detect sideroblastic changes.
doi_str_mv 10.1111/j.1751-553X.2009.01185.x
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2874264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733282922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhiMEoh_wF5BvnDbYThwnFyRU0W6rFQgVRG-D44w3XrJxamfp7r-v011t4YYP9kgz88w7fpOEMJqyeD6sUiYFmwmR3aWc0iqljJUi3b5ITo-Jl8eYs5PkLIQVpULmtHqdnLBK0oIWxWny69Y26F3dqTBaTXSr-iUG4gwZWyS165GslffugWjVkxrJ4LGxesSG1LunGvS7sfVu6dV6ahvQ26FFrzpSd841b5JXRnUB3x7e8-TH5efvF_PZ4uvV9cWnxUwLxkW8aV1IgUIjM5mMOg0zhhqp68xgVcf9TNFkXCud56riFZd5SaUwVKBshMzOk4977rCp19ho7MeoAQZvo_4dOGXh30xvW1i6P8BLmfMij4D3B4B39xsMI6xt0Nh1qke3CSCzjJdxLo-V5b5SexeCR3OcwihM_sAKpq-HyQaY_IEnf2AbW9_9rfK58WDI8xoPtsPdf4Ph-mYxn8IImO0BNoy4PQKU_w2FzKSAn1-u4I59m9-Wlzcwzx4B2_-wow</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733282922</pqid></control><display><type>article</type><title>Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>ROVÓ, A. ; STÜSSI, G. ; MEYER-MONARD, S. ; FAVRE, G. ; TSAKIRIS, D. ; HEIM, D. ; HALTER, J. ; ARBER, C. ; PASSWEG, J. ; GRATWOHL, A. ; TICHELLI, A.</creator><creatorcontrib>ROVÓ, A. ; STÜSSI, G. ; MEYER-MONARD, S. ; FAVRE, G. ; TSAKIRIS, D. ; HEIM, D. ; HALTER, J. ; ARBER, C. ; PASSWEG, J. ; GRATWOHL, A. ; TICHELLI, A.</creatorcontrib><description>Summary The diagnosis of sideroblastic anemia is based on bone marrow aspiration, and the detection of ring sideroblasts (RS) in iron staining. The finding of laboratory parameters to approach this diagnosis still remains a great challenge. In this study, we analyzed the value of a specific erythrogram pattern from peripheral blood, produced by the ADVIA®120 cell counter, to predict sideroblastic changes in the bone marrow. In a two step‐design study, we first showed that 32/38 consecutive patients reporting ≥15% RS had such a pattern in the erythrogram. In the second step, we prospectively identified over a period of 32 months 21 patients with this typical erythrogram; 20/21 had ≥15% RS in the bone marrow. Hence, by this validation, we confirm that the erythrogram is highly predictive of RS in the bone marrow. The interpretation of the erythrogram should become daily practice in hematology to improve the efficacy to detect sideroblastic changes.</description><identifier>ISSN: 1751-5521</identifier><identifier>EISSN: 1751-553X</identifier><identifier>DOI: 10.1111/j.1751-553X.2009.01185.x</identifier><identifier>PMID: 19706066</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anemia, Sideroblastic - blood ; Anemia, Sideroblastic - diagnosis ; Bone Marrow - physiopathology ; Erythroblasts - cytology ; Erythrocyte Indices ; erythrogram ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; myelodysplastic syndromes ; myeloid neoplasms ; Original ; Predictive Value of Tests ; Ring sideroblasts ; scattergram ; sideroblastic anemia ; Young Adult</subject><ispartof>International journal of laboratory hematology, 2010-06, Vol.32 (3), p.329-335</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd</rights><rights>Journal compilation © 2010 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573</citedby><cites>FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19706066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROVÓ, A.</creatorcontrib><creatorcontrib>STÜSSI, G.</creatorcontrib><creatorcontrib>MEYER-MONARD, S.</creatorcontrib><creatorcontrib>FAVRE, G.</creatorcontrib><creatorcontrib>TSAKIRIS, D.</creatorcontrib><creatorcontrib>HEIM, D.</creatorcontrib><creatorcontrib>HALTER, J.</creatorcontrib><creatorcontrib>ARBER, C.</creatorcontrib><creatorcontrib>PASSWEG, J.</creatorcontrib><creatorcontrib>GRATWOHL, A.</creatorcontrib><creatorcontrib>TICHELLI, A.</creatorcontrib><title>Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood</title><title>International journal of laboratory hematology</title><addtitle>Int J Lab Hematol</addtitle><description>Summary The diagnosis of sideroblastic anemia is based on bone marrow aspiration, and the detection of ring sideroblasts (RS) in iron staining. The finding of laboratory parameters to approach this diagnosis still remains a great challenge. In this study, we analyzed the value of a specific erythrogram pattern from peripheral blood, produced by the ADVIA®120 cell counter, to predict sideroblastic changes in the bone marrow. In a two step‐design study, we first showed that 32/38 consecutive patients reporting ≥15% RS had such a pattern in the erythrogram. In the second step, we prospectively identified over a period of 32 months 21 patients with this typical erythrogram; 20/21 had ≥15% RS in the bone marrow. Hence, by this validation, we confirm that the erythrogram is highly predictive of RS in the bone marrow. The interpretation of the erythrogram should become daily practice in hematology to improve the efficacy to detect sideroblastic changes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia, Sideroblastic - blood</subject><subject>Anemia, Sideroblastic - diagnosis</subject><subject>Bone Marrow - physiopathology</subject><subject>Erythroblasts - cytology</subject><subject>Erythrocyte Indices</subject><subject>erythrogram</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myelodysplastic syndromes</subject><subject>myeloid neoplasms</subject><subject>Original</subject><subject>Predictive Value of Tests</subject><subject>Ring sideroblasts</subject><subject>scattergram</subject><subject>sideroblastic anemia</subject><subject>Young Adult</subject><issn>1751-5521</issn><issn>1751-553X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqNkU1v1DAQhiMEoh_wF5BvnDbYThwnFyRU0W6rFQgVRG-D44w3XrJxamfp7r-v011t4YYP9kgz88w7fpOEMJqyeD6sUiYFmwmR3aWc0iqljJUi3b5ITo-Jl8eYs5PkLIQVpULmtHqdnLBK0oIWxWny69Y26F3dqTBaTXSr-iUG4gwZWyS165GslffugWjVkxrJ4LGxesSG1LunGvS7sfVu6dV6ahvQ26FFrzpSd841b5JXRnUB3x7e8-TH5efvF_PZ4uvV9cWnxUwLxkW8aV1IgUIjM5mMOg0zhhqp68xgVcf9TNFkXCud56riFZd5SaUwVKBshMzOk4977rCp19ho7MeoAQZvo_4dOGXh30xvW1i6P8BLmfMij4D3B4B39xsMI6xt0Nh1qke3CSCzjJdxLo-V5b5SexeCR3OcwihM_sAKpq-HyQaY_IEnf2AbW9_9rfK58WDI8xoPtsPdf4Ph-mYxn8IImO0BNoy4PQKU_w2FzKSAn1-u4I59m9-Wlzcwzx4B2_-wow</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>ROVÓ, A.</creator><creator>STÜSSI, G.</creator><creator>MEYER-MONARD, S.</creator><creator>FAVRE, G.</creator><creator>TSAKIRIS, D.</creator><creator>HEIM, D.</creator><creator>HALTER, J.</creator><creator>ARBER, C.</creator><creator>PASSWEG, J.</creator><creator>GRATWOHL, A.</creator><creator>TICHELLI, A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201006</creationdate><title>Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood</title><author>ROVÓ, A. ; STÜSSI, G. ; MEYER-MONARD, S. ; FAVRE, G. ; TSAKIRIS, D. ; HEIM, D. ; HALTER, J. ; ARBER, C. ; PASSWEG, J. ; GRATWOHL, A. ; TICHELLI, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia, Sideroblastic - blood</topic><topic>Anemia, Sideroblastic - diagnosis</topic><topic>Bone Marrow - physiopathology</topic><topic>Erythroblasts - cytology</topic><topic>Erythrocyte Indices</topic><topic>erythrogram</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myelodysplastic syndromes</topic><topic>myeloid neoplasms</topic><topic>Original</topic><topic>Predictive Value of Tests</topic><topic>Ring sideroblasts</topic><topic>scattergram</topic><topic>sideroblastic anemia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROVÓ, A.</creatorcontrib><creatorcontrib>STÜSSI, G.</creatorcontrib><creatorcontrib>MEYER-MONARD, S.</creatorcontrib><creatorcontrib>FAVRE, G.</creatorcontrib><creatorcontrib>TSAKIRIS, D.</creatorcontrib><creatorcontrib>HEIM, D.</creatorcontrib><creatorcontrib>HALTER, J.</creatorcontrib><creatorcontrib>ARBER, C.</creatorcontrib><creatorcontrib>PASSWEG, J.</creatorcontrib><creatorcontrib>GRATWOHL, A.</creatorcontrib><creatorcontrib>TICHELLI, A.</creatorcontrib><collection>Istex</collection><collection>Wiley Open Access</collection><collection>Wiley Online Library website</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of laboratory hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROVÓ, A.</au><au>STÜSSI, G.</au><au>MEYER-MONARD, S.</au><au>FAVRE, G.</au><au>TSAKIRIS, D.</au><au>HEIM, D.</au><au>HALTER, J.</au><au>ARBER, C.</au><au>PASSWEG, J.</au><au>GRATWOHL, A.</au><au>TICHELLI, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood</atitle><jtitle>International journal of laboratory hematology</jtitle><addtitle>Int J Lab Hematol</addtitle><date>2010-06</date><risdate>2010</risdate><volume>32</volume><issue>3</issue><spage>329</spage><epage>335</epage><pages>329-335</pages><issn>1751-5521</issn><eissn>1751-553X</eissn><abstract>Summary The diagnosis of sideroblastic anemia is based on bone marrow aspiration, and the detection of ring sideroblasts (RS) in iron staining. The finding of laboratory parameters to approach this diagnosis still remains a great challenge. In this study, we analyzed the value of a specific erythrogram pattern from peripheral blood, produced by the ADVIA®120 cell counter, to predict sideroblastic changes in the bone marrow. In a two step‐design study, we first showed that 32/38 consecutive patients reporting ≥15% RS had such a pattern in the erythrogram. In the second step, we prospectively identified over a period of 32 months 21 patients with this typical erythrogram; 20/21 had ≥15% RS in the bone marrow. Hence, by this validation, we confirm that the erythrogram is highly predictive of RS in the bone marrow. The interpretation of the erythrogram should become daily practice in hematology to improve the efficacy to detect sideroblastic changes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19706066</pmid><doi>10.1111/j.1751-553X.2009.01185.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1751-5521
ispartof International journal of laboratory hematology, 2010-06, Vol.32 (3), p.329-335
issn 1751-5521
1751-553X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2874264
source Wiley-Blackwell Read & Publish Collection
subjects Adult
Aged
Aged, 80 and over
Anemia, Sideroblastic - blood
Anemia, Sideroblastic - diagnosis
Bone Marrow - physiopathology
Erythroblasts - cytology
Erythrocyte Indices
erythrogram
Female
Humans
Longitudinal Studies
Male
Middle Aged
myelodysplastic syndromes
myeloid neoplasms
Original
Predictive Value of Tests
Ring sideroblasts
scattergram
sideroblastic anemia
Young Adult
title Sideroblastic changes of the bone marrow can be predicted by the erythrogram of peripheral blood
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T00%3A03%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sideroblastic%20changes%20of%20the%20bone%20marrow%20can%20be%20predicted%20by%20the%20erythrogram%20of%20peripheral%20blood&rft.jtitle=International%20journal%20of%20laboratory%20hematology&rft.au=ROV%C3%93,%20A.&rft.date=2010-06&rft.volume=32&rft.issue=3&rft.spage=329&rft.epage=335&rft.pages=329-335&rft.issn=1751-5521&rft.eissn=1751-553X&rft_id=info:doi/10.1111/j.1751-553X.2009.01185.x&rft_dat=%3Cproquest_pubme%3E733282922%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5125-c50b675e5ce1f37740f1ff0f7cb3fe9b118f6d32cac44a9292748075f05e7d573%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733282922&rft_id=info:pmid/19706066&rfr_iscdi=true