Current status on Alzheimer disease molecular genetics: from past, to present, to future

Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genes—amyloid precursor protein and presenilin 1 and 2 genes—and one risk gene apolipoprotein E (APOE), no...

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Bibliographic Details
Published in:Human molecular genetics 2010-04, Vol.19 (R1), p.R4-R11
Main Authors: Bettens, Karolien, Sleegers, Kristel, Van Broeckhoven, Christine
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Genetic Linkage
Genetic Predisposition to Disease
Humans
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Summary:Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genes—amyloid precursor protein and presenilin 1 and 2 genes—and one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddq142