The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women

Although androgens may play an etiologic role in breast, ovarian and endometrial cancers, little is known about factors that influence circulating androgen levels. We conducted a cross‐sectional analysis among 646 postmenopausal women in the Nurses' Health Study to examine associations between...

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Bibliographic Details
Published in:International journal of cancer 2010-01, Vol.126 (1), p.199-207
Main Authors: Danforth, Kim N., Eliassen, A. Heather, Tworoger, Shelley S., Missmer, Stacey A., Barbieri, Robert L., Rosner, Bernard A., Colditz, Graham A., Hankinson, Susan E.
Format: Article
Language:English
Subjects:
Adult
androgens
Androgens - blood
Biological and medical sciences
Body Mass Index
Breast Neoplasms - blood
cancer risk factors
Cross-Sectional Studies
endogenous hormones
Endometrial Neoplasms - blood
epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Life Style
Medical sciences
Middle Aged
Ovarian Neoplasms - blood
Postmenopause
Risk Factors
Tumors
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Summary:Although androgens may play an etiologic role in breast, ovarian and endometrial cancers, little is known about factors that influence circulating androgen levels. We conducted a cross‐sectional analysis among 646 postmenopausal women in the Nurses' Health Study to examine associations between adult risk factors for cancer, including the Rosner/Colditz breast cancer risk score, and plasma levels of testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). All analyses were adjusted for age, laboratory batch and other cancer risk factors. Free testosterone levels were 79% higher among women with a body mass index of ≥30 vs. 30 g of alcohol a day vs. none was associated with a 31% increase in DHEA and 59% increase in DHEAS levels (p‐trend = 0.01 and
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.24709