Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats

This study focuses on the effect of 'Diashis', a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and meta...

Full description

Saved in:
Bibliographic Details
Published in:International journal of Ayurveda research 2010-01, Vol.1 (1), p.18-24
Main Authors: Bera, Tushar K, De, Debasis, Chatterjee, Kausik, Ali, Kazi M, Ghosh, Debidas
Format: Article
Language:English
Subjects:
Antioxidants
Ayurvedic medicine
Blood sugar
Care and treatment
Chemical properties
Clinical outcomes
Complications and side effects
Composition
Control
Diabetes
Health aspects
Herbal medicine
Medicine, Botanic
Medicine, Herbal
Original
Oxidative stress
Patient outcomes
Streptozocin
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study focuses on the effect of 'Diashis', a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with 'Diashis' in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by 'Diashis' which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. 'Diashis' was not found to have any metabolic toxicity. The antidiabetic effects of 'Diashis' were compared with those of the antidiabetic drug, 'Glibenclamide'.
ISSN:0974-7788
0974-925X
DOI:10.4103/0974-7788.59939