Targeted nanodelivery of drugs and diagnostics

Nanomaterials for targeted delivery are uniquely capable of localizing delivery of therapeutics and diagnostics to diseased tissues. The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patie...

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Bibliographic Details
Published in:Nano today 2010-04, Vol.5 (2), p.143-159
Main Authors: Phillips, Margaret A., Gran, Martin L., Peppas, Nicholas A.
Format: Article
Language:English
Subjects:
Active targeting
Biodistribution
Drug loading
Targeted drug delivery
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Summary:Nanomaterials for targeted delivery are uniquely capable of localizing delivery of therapeutics and diagnostics to diseased tissues. The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patient outcomes along with reduced systemic dosing. In this review, the design of targeted nanodelivery systems is discussed with an emphasis on in vivo performance, the physicochemical properties that affect localization at the target site, and the incorporation of therapeutic drugs into these systems.
ISSN:1748-0132
1878-044X
DOI:10.1016/j.nantod.2010.03.003