PD-1, gender, and autoimmunity

Abstract Programmed death 1 (PD-1) and its ligands (PD-L1 and PD-L2) are responsible for inhibitory T cell signaling that helps mediate the mechanisms of tolerance and immune homeostasis. The PD-1:PD-L signaling pathway has been shown to play an important role in a variety of diseases, including aut...

Full description

Saved in:
Bibliographic Details
Published in:Autoimmunity reviews 2010-06, Vol.9 (8), p.583-587
Main Authors: Dinesh, Ravi K, Hahn, Bevra H, Singh, Ram Pyare
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoimmunity
Gender
Immune system
PD-1
Sex hormones
Systemic lupus erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Programmed death 1 (PD-1) and its ligands (PD-L1 and PD-L2) are responsible for inhibitory T cell signaling that helps mediate the mechanisms of tolerance and immune homeostasis. The PD-1:PD-L signaling pathway has been shown to play an important role in a variety of diseases, including autoimmune conditions, chronic infection, and cancer. Recently, investigators have explored the role of sex hormones in modulating the pathway in autoimmune conditions. Exploring the effects of sex hormones on the PD-1:PD-L pathway could shed light on the gender biased nature of many autoimmune conditions as well as aide in the development of therapeutics targeting the immune system.
ISSN:1568-9972
1568-9972
1873-0183
DOI:10.1016/j.autrev.2010.04.003