Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats

Hyperglycemia exerts toxic effects on the pancreatic beta-cells. This study investigated the hypothesis that the common antidiabetic drugs glibenclamide and metformin, in combination with tualang honey, offer additional protection for the pancreas of streptozotocin (STZ)-induced diabetic rats agains...

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Published in:International journal of molecular sciences 2010-05, Vol.11 (5), p.2056-2066
Main Authors: Erejuwa, Omotayo Owomofoyon, Sulaiman, Siti Amrah, Wahab, Mohd Suhaimi Abdul, Salam, Sirajudeen Kuttulebbai Nainamohammed, Salleh, Md Salzihan Md, Gurtu, Sunil
Format: Article
Language:English
Subjects:
Animals
Antidiabetics
Antioxidants
Antioxidants - pharmacology
Diabetes
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Experimental - prevention & control
Enzymes
Free radicals
Gene Expression Regulation, Enzymologic - drug effects
Glucose
Glyburide - pharmacology
Honey
Hypoglycemic Agents - pharmacology
Laboratory animals
Lipid peroxidation
Male
Metformin - pharmacology
Oxidation
Oxidative stress
Oxidative Stress - drug effects
Oxidoreductases - biosynthesis
Pancreas
Pancreas - enzymology
Pancreas - physiopathology
Rats
Rats, Sprague-Dawley
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Summary:Hyperglycemia exerts toxic effects on the pancreatic beta-cells. This study investigated the hypothesis that the common antidiabetic drugs glibenclamide and metformin, in combination with tualang honey, offer additional protection for the pancreas of streptozotocin (STZ)-induced diabetic rats against oxidative stress and damage. Diabetes was induced in male Sprague Dawley rats by a single dose of STZ (60 mg/kg; ip). Diabetic rats had significantly elevated levels of lipid peroxidation (TBARS), up-regulated activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) while catalase (CAT) activity was significantly reduced. Glibenclamide and metformin produced no significant effects on TBARS and antioxidant enzymes except GPx in diabetic rats. In contrast, the combination of glibenclamide, metformin and honey significantly up-regulated CAT activity and down-regulated GPx activity while TBARS levels were significantly reduced. These findings suggest that tualang honey potentiates the effect of glibenclamide and metformin to protect diabetic rat pancreas against oxidative stress and damage.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms11052056