Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women

This study investigated the effect of sildenafil on uterine volumetric blood flow (UVF) and vascular impedance in nonpregnant, nulliparous women. Fifteen women were randomized in a double-blind fashion to receive either placebo or sildenafil (25 or 100 mg) during the luteal phase of the menstrual cy...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2010-04, Vol.17 (4), p.358-365
Main Authors: Hale, Sarah A., Jones, Cresta W., Osol, George, Schonberg, Adrienne, Badger, Gary J., Bernstein, Ira M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Embryology
Female
Gynecology. Andrology. Obstetrics
Hemodynamics - drug effects
Humans
Luteal Phase - blood
Luteal Phase - drug effects
Medical sciences
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original Article
Phosphodiesterase Inhibitors - blood
Phosphodiesterase Inhibitors - pharmacology
Piperazines - blood
Piperazines - pharmacology
Purines - blood
Purines - pharmacology
Regional Blood Flow - drug effects
Reproductive Medicine
Sildenafil Citrate
Sulfones - blood
Sulfones - pharmacology
Uterine Artery - drug effects
Uterus - blood supply
Vasodilator Agents - blood
Vasodilator Agents - pharmacology
Young Adult
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Summary:This study investigated the effect of sildenafil on uterine volumetric blood flow (UVF) and vascular impedance in nonpregnant, nulliparous women. Fifteen women were randomized in a double-blind fashion to receive either placebo or sildenafil (25 or 100 mg) during the luteal phase of the menstrual cycle. Color Doppler ultrasound of both uterine arteries was performed at baseline and at 1 and 3 hours postdosing to calculate resistance index (RI) and UVF. Those who received sildenafil significantly increased UVF and decreased RI over the 3-hour monitoring period. When UVF responses to sildenafil were examined as a function of baseline UVF, a significant increase in UVF was observed in only those participants with higher baseline UVF. Overall, women in the luteal phase demonstrated a significant increase in UVF in response to sildenafil. However, this increase appears to be directly associated with basal UVF.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719109354648