Role of the glucagon-like-peptide-1 receptor in the control of energy balance

Abstract The peripheral and central glucagon-like-peptide-1 (GLP-1) systems play an essential role in glycemic and energy balance regulation. Thus, pharmacological targeting of peripheral and/or central GLP-1 receptors (GLP-1R) may represent a potential long-term treatment option for both obesity an...

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Bibliographic Details
Published in:Physiology & behavior 2010-07, Vol.100 (5), p.503-510
Main Authors: Hayes, Matthew R, De Jonghe, Bart C, Kanoski, Scott E
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
Brain stem
Drug Administration Routes
Eating - drug effects
Eating - physiology
Energy Metabolism - physiology
Fundamental and applied biological sciences. Psychology
Glucagon-Like Peptide 1 - metabolism
Glucagon-Like Peptide 1 - pharmacology
Glucagon-Like Peptide-1 Receptor
Humans
Incretins - metabolism
Incretins - pharmacology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Receptors, Glucagon - physiology
Signal Transduction - drug effects
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Summary:Abstract The peripheral and central glucagon-like-peptide-1 (GLP-1) systems play an essential role in glycemic and energy balance regulation. Thus, pharmacological targeting of peripheral and/or central GLP-1 receptors (GLP-1R) may represent a potential long-term treatment option for both obesity and type-II diabetes mellitus (T2DM). Uncovering and understanding the neural pathways, physiological mechanisms, specific GLP-1R populations, and intracellular signaling cascades that mediate the food intake inhibitory and incretin effects produced by GLP-1R activation are vital to the development of these potential successful therapeutics. Particular focus will be given to the essential role of the nucleus tractus solitarius (NTS) in the caudal brainstem, as well as the gut-to-brain communication by vagal afferent fibers in mediating the physiological and behavioral responses following GLP-1R activation. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
ISSN:0031-9384
1873-507X
1873-507X
DOI:10.1016/j.physbeh.2010.02.029