Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:A meta-analysis

• Published in: World journal of gastroenterology : WJG 2010-06, Vol.16 (23), p.2931-2942
• Main Authors: Miao, Ruo-Yu, Zhao, Hai-Tao, Yang, Hua-Yu, Mao, Yi-Lei, Lu, Xin, Zhao, Yi, Liu, Chang-Ning, Zhong, Shou-Xian, Sang, Xin-Ting, Huang, Jie-Fu
• Format: Article
• Language: English
• Subjects: Antiviral Agents - therapeutic use; Brief; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - drug therapy; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Humans; Interferons - therapeutic use; Liver Neoplasms - drug therapy; Liver Neoplasms - etiology; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Neoplasm Recurrence, Local - prevention & control; Randomized Controlled Trials as Topic; Survival Analysis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v16.i23.2931

AIM:To investigate the impact of postoperative antiviral treatment on tumor recurrence and survival of patients with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection-related primary hepatocellular carcinoma(HCC) after curative therapy.METHODS:We performed a meta-analysis of randomized and non-randomized control trials from electronic search and manual search.The fixed effect model of Mantel-Haenszel method and the random effect model of Der Simonian and Laird method were used for homogeneo...