Minimal acute rejection in pediatric lung transplantation - Does it matter?

Benden C, Faro A, Worley S, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet SC, Danziger‐Isakov LA. Minimal acute rejection in pediatric lung transplantation – Does it matter?.
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Published in:Pediatric transplantation 2010-06, Vol.14 (4), p.534-539
Main Authors: Benden, Christian, Faro, Albert, Worley, Sarah, Arrigain, Susana, Aurora, Paul, Ballmann, Manfred, Boyer, Debra, Conrad, Carol, Eichler, Irmgard, Elidemir, Okan, Goldfarb, Samuel, Mallory, George B., Mogayzel, Peter J., Parakininkas, Daiva, Solomon, Melinda, Visner, Gary, Sweet, Stuart C., Danziger-Isakov, Lara A.
Format: Article
Language:English
Subjects:
acute allograft rejection
Acute Disease
Adolescent
Biological and medical sciences
Bronchiolitis Obliterans - mortality
Bronchiolitis Obliterans - pathology
bronchiolitis obliterans syndrome
Child
Child, Preschool
children
Chronic obstructive pulmonary disease, asthma
Female
General aspects
Graft Rejection - mortality
Graft Rejection - pathology
Humans
Infant
lung transplantation
Lung Transplantation - adverse effects
Lung Transplantation - mortality
Male
Medical sciences
pediatrics
Pneumology
Retrospective Studies
Risk Factors
Severity of Illness Index
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
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Summary:Benden C, Faro A, Worley S, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet SC, Danziger‐Isakov LA. Minimal acute rejection in pediatric lung transplantation – Does it matter?.
Pediatr Transplantation 2010: 14:534–539. © 2010 John Wiley & Sons A/S. :  In adult lung transplantation, a single minimal AR episode is a significant predictor of BOS independent of other factors. However, the significance of single minimal AR episodes in children is unknown. A retrospective, multi‐center analysis was performed to determine whether isolated single AR episodes are associated with an increased BOS risk in children. Risk factors for BOS, death, or re‐transplantation, and a combined outcome of BOS, death, or re‐transplantation were assessed. Original data included 577 patients (
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2009.01268.x