Aging-related changes in calcium-binding proteins in rat perirhinal cortex

Abstract Dysregulation of intracellular calcium homeostasis has been linked to neuropathological symptoms observed in aging and age-related disease. Alterations in the distribution and relative frequency of calcium-binding proteins (CaBPs), which are important in regulating intracellular calcium lev...

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Bibliographic Details
Published in:Neurobiology of aging 2011-09, Vol.32 (9), p.1693-1706
Main Authors: Moyer, James R, Furtak, Sharon C, McGann, John P, Brown, Thomas H
Format: Article
Language:English
Subjects:
Aged
Aging - metabolism
Animals
Biological and medical sciences
Calbindin
Calbindin 1
Calbindin 2
Calbindins
Calcium-Binding Proteins - metabolism
Calcium-Binding Proteins - physiology
Calretinin
Development. Senescence. Regeneration. Transplantation
Entorhinal Cortex - chemistry
Entorhinal Cortex - metabolism
Fundamental and applied biological sciences. Psychology
Immunohistochemistry
Internal Medicine
Laminar distribution
Male
Medial temporal lobe
Memory Disorders - metabolism
Middle-aged
Neurology
Parahippocampal Gyrus - chemistry
Parahippocampal Gyrus - metabolism
Parvalbumin
Parvalbumins - physiology
Rats
Rats, Sprague-Dawley
S100 Calcium Binding Protein G - physiology
Temporal Lobe - chemistry
Temporal Lobe - metabolism
Vertebrates: nervous system and sense organs
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Summary:Abstract Dysregulation of intracellular calcium homeostasis has been linked to neuropathological symptoms observed in aging and age-related disease. Alterations in the distribution and relative frequency of calcium-binding proteins (CaBPs), which are important in regulating intracellular calcium levels, may contribute to disruption of calcium homeostasis. Here we examined the laminar distribution of three CaBPs in rat perirhinal cortex (PR) as a function of aging. Calbindin-D28k (CB), parvalbumin (PV), and calretinin (CR) were compared in adult (4 mo.), middle-aged (13 mo.) and aged (26 mo.) rats. Results show an aging-related and layer-specific decrease in the number of CB-immunoreactive (-ir) neurons, beginning in middle-aged animals. Dual labeling suggests that the age-related decrease in CB reflects a decrease in neurons that are not immunoreactive for the inhibitory neurotransmitter GABA. In contrast, no aging-related differences in PV- or CR-immunoreactivity were observed. These data suggest that selective alterations in CB-ir neurons may contribute to aging-related learning and memory deficits in tasks that depend upon PR circuitry.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2009.10.001