The Cajal body and histone locus body

The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing fa...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2010-07, Vol.2 (7), p.a000653-a000653
Main Authors: Nizami, Zehra, Deryusheva, Svetlana, Gall, Joseph G
Format: Article
Language:English
Subjects:
Amphibians
Animals
Cell Nucleus - metabolism
Coiled Bodies - metabolism
Histones - metabolism
Humans
Oocytes - metabolism
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Summary:The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing factors, suggesting that they are sites for assembly and/or posttranscriptional modification of the splicing machinery of the nucleus. The histone locus body (HLB) contains factors required for processing histone pre-mRNAs. As its name implies, the HLB is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action. CBs and HLBs are present throughout the interphase of the cell cycle, but disappear during mitosis. The biogenesis of CBs shows the features of a self-organizing structure.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a000653